Host-Vector-Parasite-Environment Interactions in Neglected Tropical Diseases due to Trypanosomatids

IRD/CIRAD/University of Bordeaux 2 - University of Lyon 1 Joint Research Unit

The Intertryp installation at CIRDES in Burkina Faso is a WHO Collaborating Centre for research on interactions in the epidemiology of human African trypanosomiasis
 CIRAD, via Intertryp, is the OIE Reference Laboratory for animal trypanosomoses.

The Challenge

The health and social burden of neglected tropical diseases caused by Trypanosomatids (NTD-TRYP) makes it necessary to control and eliminate them in compliance with the WHO 2020 Roadmap for the elimination of NTDs. Our research fits in directly with the United Nations Sustainable Development Goals (SDGs) for 2030, and in particular SDGs 2, 3 and 17.

Our Mission

With our Southern and European partners, we have adopted an integrated “One Health” approach to all aspects of the Trypanosomatid cycle—hosts, parasites, vectors, microbiota and the environment, in order to:

  • diagnose, analyse, develop and provide partners in the South and neglected populations with ways of controlling and eliminating these diseases
  • improve public and animal health, and increase food security in a context of global change

This is accompanied by a strong skill-development and capacity-building component for our partners.

Our scientific strategy

  • Understand the evolutionary trends among vectors and parasites in endemic or invasive situations, and develop novel vector control tools
  • Clarify the bases of host-parasite interactions and understand the phenomena of asymptomatic carrying/tolerance/resistance
  • Develop new prophylactic or therapeutic molecules and new strategies for interrupting the transmission of parasites and infection, and
  • Effectively contribute to the NTD-TRYP elimination process.

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